Dr. Nedwin has over 30 years experience in the pharmaceutical and industrial biotechnology industries. He is an accomplished senior executive with domestic and international experience in new market identification, innovation, research & development, business planning, strategic positioning, operations, P&L, sales & marketing, involving both start-up, growth and billion dollar organizations. He has a track record of innovative product development, market focus, increasing sales and EBIT while spearheading operational improvements to drive productivity and increase efficiency.
Dr. Nedwin received his B.S. degree in Biochemistry from S.U.N.Y./Buffalo and a Ph.D. in Biochemistry from U.C. Riverside. He did a post-doctoral fellowship in Molecular Biology at Genentech, Inc. Dr. Nedwin also holds a M.S. Degree in the Management of Technology from the Massachusetts Institute of Technology. Dr. Nedwin has held a number of varied scientific, corporate development and senior management positions, most notably as President of Novozymes, Inc., and as Executive Vice President of the Genencor Technical Enzymes Division of Danisco (acquired by DuPont in 2011). More recently, Dr. Nedwin was CEO of Taxon Biosciences, Inc., (acquired by DuPont in April 2015). He is currently CEO of TripleDNA Consulting, LLC. Dr. Nedwin is a co-author of over 40 scientific publications and patents and co-editor in chief of the journal Industrial Biotechnology. Dr. Nedwin has served on several Boards, including the UC Davis Foundation Board of Trustees. He is a current and founding member of the Board of Executives of the UCD Robert Mondavi Institute of Wine and Food Science.
Karim Dabbagh leads the R&D organization at Second Genome. Prior to that, he led the immunoregulation department at Pfizer, an R&D group focused on innovative approaches to elicit homeostatic immune responses, including microbiome research, for the treatment of immune related disorders. At Pfizer, he also led external R&D innovation for autoimmune and inflammatory diseases. Past responsibilities include founding Modus BioMedicine, a start-up biotechnology company focused on treatments for transplantation and autoimmune disease, as well as spending nine years at Roche Pharmaceuticals in Inflammation Discovery Research. Dr. Dabbagh received his PhD in biochemistry from University College, London and his BS in biotechnology from the Imperial College of Science, Technology, and Medicine in London. He completed postdoctoral fellowships at the Cardiovascular Research Institute at the University of California, San Francisco and at Stanford University where he worked on elucidating the role played by the microbiome in the hygiene hypothesis.
Dr. McClure leads all clinical, clinical operations, and regulatory activities at Second Genome. He brings more than 20 years of experience in clinical/translational medicine, drug development, and therapeutic strategy, with specific expertise in liver disease, inflammation, thrombosis/coagulation, fibrosis, and infectious diseases.
During his career, Dr. McClure has played a central role in the clinical development of multiple approved/promising molecules, including Esbriet®/pirfenidone at InterMune (which resulted in an $8.3 billion acquisition by Roche), Andexxa®/andexanet alfa at Portola Pharmaceuticals, and lumicitabine at Alios BioPharma (which resulted in a $1.75 billion acquisition by Johnson & Johnson (JNJ)). Dr. McClure has also served in roles of increasing responsibility, with his most recent position at JNJ being responsible for all aspects of the simultaneous development of three compounds in the infectious diseases area. He has also co-authored multiple peer-reviewed publications in high impact journals including the New England Journal of Medicine and Circulation.
Prior to joining industry, Dr. McClure worked as a hospitalist after earning a medical doctorate and completing a residency in internal medicine, both at Duke University. He earned a bachelor of science degree in biochemistry and cell biology at the University of California, San Diego.
As Senior Vice President, Finance & Controller, Brian Dowd leads all financial and transactional operations at Second Genome. He has over 25 years’ experience in financial operations for life science and technology companies with domestic and international operations. He has lead company’s finance operations through the transition from a private company to a publicly traded company via initial public offerings or acquisitions.
Mr. Dowd started his career at Deloitte and has held a number of senior level financial management positions. Most recently, through November, 2016, he was Vice President, Controller of Johnson & Johnson's Janssen Pharmaceutical's Alios Biopharma, which was acquired by Johnson & Johnson in November, 2014. Prior to Johnson and Johnson, he held numerous roles at Codexis, Inc. and prior to Codexis, VeriFone Holdings.
Mr. Dowd received his B.S. degree in Business Administration from California Polytechnic University San Luis Obispo. He is formerly a member of the Board of Trustees at The Carey School and is presently a Board Member of the Belmont Redwood Shores Little League.
Mr. Sjoerdsma brings more than 25 years of experience in human resources to his position, in which he will lead all recruitment, hiring, onboarding, training and organizational development of Second Genome employees. Prior to his current role, Sjoerdsma served in various roles in human resources for Genencor at all stages of its growth – from start-up to publicly traded to its acquisition by DuPoint BioSciences. While at Genencor, he developed a corporate culture that led to the company’s recognition as a “Great Place to Work” in four countries, including awards as the top company of its size by Fortune Magazine and the San Francisco Chronicle. Sjoerdsma earned his master’s degree in business administration from Nova Southeastern University and his bachelor’s degree in economics and business from Cornell College. Sjoerdsma holds an executive certificate in strategy and organization from Stanford University.
Todd DeSantis is Second Genome Co-founder and Vice-President of Informatics. Todd has 17 years of experience designing and implementing bioinformatics solutions for analyzing microbial community dynamics. At Lawrence Berkeley National Laboratory he led the development of novel microbiome assays and analysis pipelines as a Molecular Microbial Ecology Software Developer. He is the chief architect of GreengenesTM, an international effort to catalog global microbial diversity that provides microbial ecologists with reference databases for DNA quality assessment, alignment and classification. Todd also served as an analyst for the NIH Human Microbiome Project and has published over 60 scientific papers. At Second Genome, he manages all informatics work including identifying and recruiting microbiome scientist leaders, integration of multi-omics pipelines, cloud deployment for big-data analytics, and therapeutic pathway discovery.